NCIt definition : An injectable emulsion formulation containing the taxane docetaxel, a semisynthetic
analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically
to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting
microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and
cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial
growth factor (VEGF) and induces various mediators of the inflammatory response. Docetaxel
emulsion ANX-514 is formulated without polysorbate 80 or other detergents in order
to reduce the incidence and severity of hypersensitivity reactions. In addition, the
exclusion of polysorbate 80 in this formulation precludes foaming during the preparation
process, thus facilitating preparation and administration.;
Semantic type(s)