Stage IV Mycosis Fungoides AJCC v7

Preferred Label : Stage IV Mycosis Fungoides AJCC v7;

NCIt synonyms : Mycosis Fungoides Stage IV; Stage IV Mycosis Fungoides;

NCIt definition : Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque /- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque /- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone. (AJCC 7th ed.);

Neoplastic status : Malignant;

Details

Origin ID

C7802;

UMLS CUI

C0278573;

Automatic exact mappings (from CISMeF team)
- Mycosis fungoides stage IV [MedDRA LLT]
Currated CISMeF NLP mapping
- mycosis fungoides stage iv [MedDRA Preferred Term]
Disease excludes abnormal cell
- Neoplastic B-Lymphocyte [NCIt concept]
- Reed-Sternberg Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Plasma Cell [NCIt concept]
- Precursor Natural Killer Cell [NCIt concept]
- Precursor T-Lymphoblast [NCIt concept]
Disease may have findings
- Chronic Clinical Course [NCIt concept]
- Dermatopathic Lymphadenopathy [NCIt concept]
- Pautrier Microabscess Present [NCIt concept]
- Progressive Disease [NCIt concept]
- Scaly Skin Eruption [NCIt concept]
- Single Cell Exocytosis [NCIt concept]
- Skin Patch [NCIt concept]
- Skin Plaque [NCIt concept]
Excludes anatomical site(s)
- Lymph Node [NCIt concept]
False automatic mappings
- Mycosis fungoides (Working Formulation) stage IV [MedDRA LLT]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
- Integumentary System [NCIt concept]
- Skin [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Mycosis fungoides stage IV [MedDRA LLT]
- mycosis fungoides stage iv [MedDRA Preferred Term]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Aggressive Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Cerebriform Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
disease_has_finding
- Cutaneous Involvement [NCIt concept]
- Epidermotropic Lymphocytic Infiltrate [NCIt concept]
- Extracutaneous Dissemination of Disease [NCIt concept]
- Extranodal Disease [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte [NCIt concept]
- Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell [NCIt concept]
- Peripheral Epidermotropic T-Lymphocyte [NCIt concept]
- T-Lymphocyte and Natural Killer Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
- Skin [NCIt concept]
disease_is_stage
- AJCC v7 Stage [NCIt concept]
- Stage IV [NCIt concept]
disease_may_have_molecular_abnormality
- CDKN2A Gene Inactivation [NCIt concept]
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]

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