Preferred Label : Cidofovir Anhydrous;
NCIt definition : An anhydrous form of cidofovir, a synthetic, acyclic monophosphate nucleotide analog
of deoxycytidine with antiviral activity, mostly used against cytomegalovirus (CMV).
After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases
to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural
similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral
DNA polymerase and gets incorporated into the growing viral DNA strands. As a result,
it prevents further DNA polymerization and disrupts DNA replication of viruses.;
UNII : 768M1V522C;
InChIKey : VWFCHDSQECPREK-LURJTMIESA-N;
CAS number : 113852-37-2;
Chemical formula : C8H14N3O6P;
ChEBI ID : CHEBI:3696;
Origin ID : C77925;
UMLS CUI : C2699210;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
