Preferred Label : Iodine I 123 Anti-CEA Recombinant Diabody T84.66;
NCIt synonyms : Iodine I 123 Anti-CEA Recombinant Diabody T84 66;
NCIt definition : A radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal
antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123)
with potential radioimmunolocalization applications. The antibody moiety of iodine
I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively
delivering I-123 upon cellular internalization and allowing the scintigraphic imaging
of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in
many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid
cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages
of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution,
and a lower potential for eliciting an immune response.;
NCI Metathesaurus CUI : CL383557;
Origin ID : C77911;
UMLS CUI : C2697812;
Semantic type(s)
- concept_is_in_subset
- has_target
