Preferred Label : Ad-sig-hMUC-1/ecdCD40L Vaccine;
NCIt synonyms : Ad-sig-hMUC-1/ecdCD40L Adenoviral Vector Vaccine; Ad-sig-hMUC-1 ecdCD40L Vaccine;
NCIt definition : A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated
antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the
co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that
encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic
activities. Due to the presence of the secretory signal peptide expressed by Ad-sig
in the vaccine construct, transfected cells may secrete a fusion protein composed
of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to
CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate,
T-cells may expand, and a cytotoxic T lymphocyte (CTL) response against tumor cells
that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed
by epithelial cancer cells.;
NCI Metathesaurus CUI : CL386701;
Origin ID : C77910;
UMLS CUI : C2700160;
Semantic type(s)
- concept_is_in_subset
