Bizalimogene Ralaplasmid

Preferred Label : Bizalimogene Ralaplasmid;

NCIt synonyms : HPV DNA Plasmids Therapeutic Vaccine VGX-3100;

NCIt definition : A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and antineoplastic activities. Administered via intramuscular electroporation, bizalimogene ralaplasmid expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved in cervical carcinogenesis.;

UNII : D8W2DVO5ZJ;

CAS number : 1977488-08-6;

Molecule name : VGX-3100; pGX3002;

Details

Origin ID

C77909;

UMLS CUI

C5421244;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- VGX-3100 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein E6, Human Papillomavirus Type 16 [NCIt concept]
- Protein E6, Human Papillomavirus Type 18 [NCIt concept]
- Protein E7, Human Papillomavirus Type 16 [NCIt concept]
- Protein E7, Human Papillomavirus Type 18 [NCIt concept]

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