NCIt synonyms : HPV DNA Plasmids Therapeutic Vaccine VGX-3100;
NCIt definition : A DNA vaccine consisting of plasmids encoding the E6 and E7 genes of human papilloma
virus (HPV) subtypes 16 and 18, respectively, with potential immunostimulating and
antineoplastic activities. Administered via intramuscular electroporation, bizalimogene
ralaplasmid expresses E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte
(CTL) response against cervical cancer cells expressing E6 and E7 proteins, resulting
in tumor cell lysis. HPV type 16 and HPV type 18 are the most common HPV types involved
in cervical carcinogenesis.;
UNII : D8W2DVO5ZJ;
CAS number : 1977488-08-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1977488-08-6
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Semantic type(s)