Preferred Label : HLA-A*0201-Restricted VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt synonyms : HLA-A 0201-Restricted VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing two HLA-A*0201-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from: vascular endothelial growth factor receptors (VEGFR) 1 and 2. Upon administration,
HLA-A*0201-restricted VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic
T lymphocyte (CTL) response against tumor cells expressing VEGFR 1 and 2 peptides,
resulting in tumor cell lysis and decreased tumor growth. HLA-A*0201 is an MHC class
I molecule that presents antigenic peptides to CD8 T cells; epitope design restricted
to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide
immunogenicity.;
NCI Metathesaurus CUI : CL383613;
Origin ID : C77905;
UMLS CUI : C2697543;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
