" /> Serdemetan - CISMeF





Preferred Label : Serdemetan;

NCIt synonyms : HDM2 Inhibitor JNJ-26854165; N-(2-(1H-Indol-3-yl)ethyl)-n'-(pyridin-4-yl)benzene-1,4-diamine;

NCIt definition : An orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.;

UNII : ID6YB4W3V8;

InChIKey : CEGSUKYESLWKJP-UHFFFAOYSA-N;

CAS number : 881202-45-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 881202-45-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : JNJ-26854165; JNJ 26854165;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
16/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.