Preferred Label : RARalpha Agonist IRX5183;
NCIt synonyms : RARa Agonist IRX5183; Retinoid Analogue NRX 195183;
NCIt related terms : IRX-5183;
NCIt definition : An orally bioavailable retinoid acid receptor alpha (RARalpha) agonist and vitamin
A derivative, with potential antineoplastic activity. Upon administration, RARalpha
agonist IRX5183 binds to and activates RARalpha, which promotes RARalpha-mediated
signaling. This results in the transcription of RARalpha-responsive genes, which are
responsible for cellular differentiation and proliferation. This results in the induction
of cellular differentiation and apoptosis, and leads to the inhibition of cellular
proliferation and tumorigenesis. RARalpha is a nuclear receptor and a member of the
steroid receptor superfamily; reduced RARalpha signaling is correlated with cancer
development in a variety of cancer cell types.;
UNII : RC87L028HU;
InChIKey : PNAWUIKCVQSLFG-UHFFFAOYSA-N;
CAS number : 367273-07-2;
Molecule name : NRX 195183; IRX 5183; AGN 195183; AGN-195183; IRX5183; VTP-195183; NRX195183; VTP 195183;
Origin ID : C77899;
UMLS CUI : C2703091;
Semantic type(s)
- concept_is_in_subset
- has_target
