Preferred Label : HLA-A*2402-Restricted URLC10-TTK-KOC1 Multipeptide Vaccine;
NCIt synonyms : HLA-A 2402-Restricted URLC10-TTK-KOC1 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing three HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from URLC10 (up-regulated lung cancer 10); TTK (TTK protein kinase); and KOC1 (IGF
II mRNA Binding Protein 3). Upon administration, URLC10-TTK-KOC1 multipeptide vaccine
may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing
URLC10, TTK and KOC1 peptides, resulting in tumor cell lysis and decreased tumor growth.
HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8 T cells;
epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may
improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL383609;
Origin ID : C77897;
UMLS CUI : C2697547;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
