Epothilone KOS-1584

Preferred Label : Epothilone KOS-1584;

NCIt synonyms : 9,10-Didehydroepothilone D;

NCIt related terms : KOS-1584;

NCIt definition : A second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.;

UNII : 82481G197K;

CAS number : 350493-61-7;

Molecule name : KOS-1584;

Details

Origin ID

C77892;

UMLS CUI

C2700006;

Automatic exact mappings (from CISMeF team)
- 9,10-dehydroepothilone D [MeSH Supplementary Concept]
- 9,10-dehydroepothilone D [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KOS-1584 [MeSH Supplementary Concept]
- KOS-1584 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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