" /> Samalizumab - CISMeF





Preferred Label : Samalizumab;

NCIt synonyms : Anti-(CD200 (Antigen)) (Human-mouse Monoclonal ALXN6000 Heavy Chain), Disulfide with Human-mouse Monoclonal ALXN6000 Kappa-chain, Dimer; Anti-CD200 Monoclonal Antibody ALXN6000;

NCIt definition : A humanized monoclonal antibody directed against the human immunosuppressive molecule CD200 (OX-2) with potential immunomodulating and antineoplastic activities. Samalizumab binds to CD200, blocking the binding of CD200 to its receptor, CD200R, present on cells of the macrophage lineage; inhibition of CD200 may augment the cytotoxic T-lymphocyte (CTL) mediated immune response against CD200-expressing tumor cells. CD200 is a type 1a transmembrane protein, related to the B7 family of co-stimulatory receptors, and is upregulated on the surface of multiple hematologic malignant cells; this transmembrane protein appears to be involved in the downregulation of a Th1 (helper T cell) immune response.;

UNII : 64EUX713G6;

CAS number : 1073059-33-2;

Molecule name : ALXN6000;

NCI Metathesaurus CUI : CL383569;

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28/05/2025


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