Preferred Label : Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66;
NCIt synonyms : Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody cT84.66; Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody cT84 66;
NCIt definition : A radioimmunoconjugate comprised of a chimeric monoclonal antibody against human carcinoembryonic
antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator
tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity.
The antibody moiety of yttrium Y90 DOTA anti-CEA monoclonal antibody cT84.66 binds
to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively
delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed
in many cancer types, including gastrointestinal, breast, non-small cell lung, and
thyroid cancers.;
Molecule name : cT84.66;
NCI Metathesaurus CUI : CL387153;
Origin ID : C77885;
UMLS CUI : C2700295;
Semantic type(s)
- concept_is_in_subset
- has_target
