Preferred Label : TLR Agonist CADI-05;
NCIt synonyms : Toll-like Receptor Agonist CADI-05; Mycobacterium Indicus Pranii (Heat Killed);
NCIt definition : A poly-Toll-like receptor (TLR) agonist polyantigenic vaccine containing heat killed
Mycobacterium indicus pranii (Mycobacterium w or Mw) with potential immunostimulating
and antineoplastic activities. Upon administration, poly-TLR agonist polyantigenic
vaccine activates a number of TLRs, which may result in macrophage and plasmacytoid
dendritic cell (pDC) stimulation; secretion of interferon alpha; production of pro-inflammatory
cytokines; upregulation of co-stimulatory molecules, enhanced T and B-cell stimulatory
responses; T cell proliferation, and a Th1 immune response. TLRs are transmembrane
receptors that recognize structurally conserved microbial molecules such as bacterial
cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides, lipoarabinomannan
and flagellin, among others; immune responses stimulated by TLR activation may result
in antineoplastic effects.;
UNII : M4PN1DW08K;
Molecule name : CADI-05;
NCI Metathesaurus CUI : CL387125;
Origin ID : C77884;
UMLS CUI : C2699755;
Semantic type(s)
- concept_is_in_subset
