Preferred Label : Lexibulin;
NCIt synonyms : Tubulin Inhibitor CYT997; 1-ethyl-3-(2-methoxy-4-(5-methyl-4-(((1s)-1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea;
NCIt definition : An orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting,
and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization
in tumor blood vessel endothelial cells and tumor cells, blocking the formation of
the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result
in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.;
UNII : 2GTU230HA1;
InChIKey : MTJHLONVHHPNSI-IBGZPJMESA-N;
CAS number : 917111-44-5;
Molecule name : CYT997;
Chemical formula : C24H30N6O2;
Origin ID : C77882;
UMLS CUI : C2700089;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
