Milataxel - CISMeF

Preferred Label : Milataxel;

NCIt synonyms : Oral Milataxel;

NCIt definition : An orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.;

UNII : J41Q4S20GS;

InChIKey : XIVMHSNIQAICTR-UQYHODNASA-N;

CAS number : 352425-37-7;

Molecule name : TL139; TL-00139; MAC-321;

NCI Metathesaurus CUI : CL387339;

Details

Origin ID

C77880;

UMLS CUI

C2713557;

Automatic exact mappings (from CISMeF team)
- MAC321 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- milataxel [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- milataxel [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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