" /> Milataxel - CISMeF





Preferred Label : Milataxel;

NCIt synonyms : Oral Milataxel;

NCIt definition : An orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors.;

UNII : J41Q4S20GS;

InChIKey : XIVMHSNIQAICTR-UQYHODNASA-N;

CAS number : 352425-37-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 352425-37-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TL139; TL-00139; MAC-321;

NCI Metathesaurus CUI : CL387339;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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