Glycosylated Recombinant Human Interleukin-7 - CISMeF
Glycosylated Recombinant Human Interleukin-7NCIt concept
Preferred Label : Glycosylated Recombinant Human Interleukin-7;
NCIt synonyms : Glycosylated rhIL-7;
NCIt related terms : INTERLEUKIN-7 HUMAN RECOMBINANT;
NCIt definition : A glycosylated recombinant protein which is chemically identical to or similar to
endogenous human interleukin-7 (IL-7) with hematopoietic and immunopotentiating activities.
Naturally produced by bone marrow, thymic stromal, and spleen cells, the cytokine
interleukin-7 is a hematopoietic growth factor for progenitor B cells and T cells,
stimulating proliferation and differentiation of mature T-cells and natural killer
(NK) cells. As with glycosylated endogenous proteins, glycosylation of recombinant
proteins may fundamentally affect their biological activity, function, clearance from
circulation, and antigenicity; glycosylation of recombinant proteins that are chemically
idenitical to or similar to endogenous proteins may render protein structures and
biological activities that are more similar to those of glycosylated endogenous proteins.;