Preferred Label : HLA-A*2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt synonyms : HLA-A 2402-Restricted URLC10-KOC1-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing four HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from URLC10 (up-regulated lung cancer 10 or CO16); KOC1 (IGF II mRNA Binding Protein
3); and vascular endothelial growth factor receptors (VEGFRs) 1 and 2. Upon administration,
this multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against
URL10-, KOC1-, VEGFR1- and VEGFR2-expressing tumor cells, resulting in tumor cell
lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents
antigenic peptides to CD8 T cells; epitope design restricted to epitopes that bind
most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL387276;
Origin ID : C77875;
UMLS CUI : C2697546;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
