Preferred Label : HLA-A*2404-Restricted RNF43-TOMM34-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt synonyms : HLA-A 2404-Restricted RNF43-TOMM34-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing four HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from ring finger protein 43 (RNF43); translocase of outer mitochondrial membrane 34
(TOMM34); and vascular endothelial growth factor receptors (VEGFR) 1 and 2. Upon administration,
HLA-A*2404-restricted RNF43-TOMM34-VEGFR1-VEGFR2 multipeptide vaccine may stimulate
a cytotoxic T lymphocyte (CTL) response against tumor cells expressing RNF43, TOMM34,
and VEGFR 1 and 2 peptides, resulting in tumor cell lysis and decreased tumor growth.
HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8 T cells;
epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may
improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL383612;
Origin ID : C77867;
UMLS CUI : C2697549;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
