Preferred Label : Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327;
NCIt synonyms : TKI JNJ-26483327; Multitargeted Kinase Inhibitor JNJ-26483327;
NCIt related terms : JNJ-26483327;
NCIt definition : An orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor
with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327
binds to and inhibits several members of the epidermal growth factor receptor (EGFR)
family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and
Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting
several different signaling molecules that play crucial roles at various stages in
tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis.
In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).;
UNII : 16720VER1H;
CAS number : 807640-87-5;
Molecule name : JNJ-26483327;
Origin ID : C77866;
UMLS CUI : C2698269;
Semantic type(s)
- concept_is_in_subset
