Preferred Label : DM4-Conjugated Anti-Cripto Monoclonal Antibody BIIB015;
NCIt definition : A humanized IgG1 monoclonal antibody directed against the cell surface-associated
protein Cripto and conjugated to the maytansinoid DM4 with potential antineoplastic
activity. The monoclonal antibody moiety of DM4-conjugated anti-Cripto monoclonal
antibody BIIB015 binds to the tumor associated antigen (TAA) Cripto; upon internalization,
the DM4 moiety binds to tubulin and disrupts microtubule assembly/disassembly dynamics,
resulting in inhibition of cell division and cell growth of Cripto-expressing tumor
cells. Constitutively expressed during embryogenesis, Cripto belongs to the EGF-CFC
family of growth factor-like molecules and plays a key role in signaling pathways
of certain transforming growth factor-beta superfamily members; as a TAA, Cripto is
overexpressed in carcinomas such as those of the breast, ovary, stomach, lung, and
pancreas while its expression is absent in normal tissues.;
Molecule name : BIIB015;
Origin ID : C77864;
UMLS CUI : C2699548;
Semantic type(s)
- concept_is_in_subset
