Tyroserleutide

Preferred Label : Tyroserleutide;

NCIt synonyms : YSL;

NCIt definition : A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2 /calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation.;

UNII : L9TIM50J8N;

CAS number : 138168-48-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 138168-48-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CMS 024;

Details

Origin ID

C77856;

UMLS CUI

C1451018;

Automatic exact mappings (from CISMeF team)
- yolk syncytial layer [UBERON concept]
Currated CISMeF NLP mapping
- H-Tyr-Ser-Leu-OH [MeSH Supplementary Concept]
- H-Tyr-Ser-Leu-OH [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- H-Tyr-Ser-Leu-OH [MeSH concept]
- H-Tyr-Ser-Leu-OH [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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