Preferred Label : Enteric-Coated Zoledronic Acid Tablet MER-101;
NCIt synonyms : Zoledronic Acid Tablet; Oral Zoledronic Acid;
NCIt definition : An oral tablet formulation containing zoledronic acid combined with a proprietary
absorption enhancer for improved zoledronic acid gastrointestinal absorption with
anti-bone-resorption activity. The third-generation bisphosphonate zoledronic acid
binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and
inhibiting the formation and aggregation of these crystals. This agent also inhibits
farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition
of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of
farnesylation and geranylgeranylation during the post-translational modification of
small GTPase signalling proteins, which are important in the process of osteoclast
turnover. The proprietary absorption enhancer is a GRAS (generally-recognized-as-safe)
food additive.;
Molecule name : MER-101;
NCI Metathesaurus CUI : CL383558;
Origin ID : C77855;
UMLS CUI : C2698656;
Semantic type(s)
- concept_is_in_subset
- has_target
