NCIt definition : A recombinant bispecific monoclonal antibody directed against both CD3 and epithelial
cell adhesion molecule (EpCAM) with potential immunomodulating and antineoplastic
activities. Solitomab attaches to both CD3-expressing T lymphocytes and EpCAM-expressing
tumor cells, thereby selectively cross-linking tumor and T lymphocytes; this may result
in the recruitment of cytotoxic T lymphocytes (CTL) to T lymphocyte/tumor cell aggregates
and the CTL-mediated death of EpCAM-expressing tumor cells. CD3 is an antigen expressed
on mature T cells; EpCAM, a cell surface protein, is expressed by a variety of tumor
cells and is frequently found in head and neck cancers.;