Preferred Label : Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A;
NCIt related terms : YTTRIUM Y-90 DOTA ANTI-CEA MONOCLONAL ANTIBODY M5A;
NCIt definition : A radioimmunoconjugate consisting of a monoclonal antibody directed against the human
carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90)
via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic
activity. The antibody moiety of yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A
binds to cells expressing the CEA antigen. Upon cellular internalization, this agent
selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen,
is overexpressed in many cancer types, including gastrointestinal, breast, non-small
cell lung, and thyroid cancers.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. M5A
is a monoclonal antibody that binds to a protein called CEA on the surface of some
tumor cells. It is linked to a radioisotope called yttrium Y 90, which may help kill
the cancer cells. Yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A is a type of
radioimmunoconjugate and a type of radiopharmaceutical.;
UNII : I9O4Z8CE5L;
Molecule name : Y90-DOTA-M5A;
NCI Metathesaurus CUI : CL383554;
Codes from synonyms : CDR0000626360;
Origin ID : C77853;
UMLS CUI : C2700294;
Semantic type(s)
- concept_is_in_subset
- has_target
