Preferred Label : Disufenton Sodium;
NCIt synonyms : 1,3-Benzenedisulfonic Acid, 4-(((1,1-Dimethylethyl)oxidoimino)methyl), Disodium Salt; 2,4-Disulfophenyl-tert-butylnitrone Sodium; PBN Derivative OKN-007; 2,4-Disulfonyl PBN;
NCIt definition : A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma
activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown,
this agent appears to inhibit cancer cell proliferation and migration. This agent
appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase
that is overexpressed in the extracellular matrix of cancer cells and catalyzes the
removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may
induce changes in tumor metabolism and scavenge free radicals.;
UNII : 7M1J3HN9VO;
InChIKey : XLZOVRYBVCMCGL-BPNVQINPSA-L;
CAS number : 168021-79-2;
Molecule name : NXY-059; OKN-007; HPN-07;
Chemical formula : C11H13NO7S2.2Na;
Origin ID : C77600;
UMLS CUI : C1701245;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
