Preferred Label : Molgramostim;
NCIt definition : A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF),
with potential immunostimulating activity. Upon administration as inhalation solution
via nebulizer, molgramostim binds to specific cell surface receptors and promotes
or restores GM-CSF signaling, thereby modulating the proliferation and differentiation
of a variety of hematopoietic progenitor cells with some specificity towards stimulation
of leukocyte production. This agent also activates neutrophils, monocytes, macrophages,
and dendritic cells and promotes antigen presentation, upregulates antibody-dependent
cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated
killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant
clearing by pulmonary alveolar macrophages.;
UNII : B321AL142J;
CAS number : 99283-10-0;
Drug name : Macrogen; Leucomax; Molgradex;
Molecule name : Sch 39300;
Origin ID : C77591;
UMLS CUI : C0218633;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
