Preferred Label : Terlipressin;
NCIt synonyms : N-(N-(N-Glycylglycyl)Glycyl)-8-L-Lysinevasopressin; Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-Nh2 (4-9 Disulfide);
NCIt definition : A synthetic triglycyllysine derivative of vasopressin with vasoconstrictive, antihemorrhagic,
and antidiuretic properties. Upon intravenous administration, terlipressin, an inactive
prodrug, is biotransformed to its active moiety, lysine vasopressin (LVP), a nonselective
vasopressin analogue with affinity for vasopressin receptors V1 (V1a), V2 and V3 (V1b).
As a V1 agonist, terlipressin increases systemic vascular resistance, particularly
in the splanchnic area, resulting in a decrease of portal pressure. V1 binding also
promotes platelet aggregation and glycogenolysis, while V3 binding induces adrenocorticotropic
hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect
on V2 receptors, which are responsible for promotion of water reabsorption in the
collecting ducts of the kidney via stimulation of cyclic AMP production.;
UNII : 7Z5X49W53P;
CAS number : 14636-12-5;
Chemical formula : C52H74N16O15S2;
Origin ID : C77387;
UMLS CUI : C0145185;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
