Preferred Label : Alestramustine;
NCIt definition : The l-alanine ester form of estramustine, a combination of the nitrogen mustard normustine
coupled via a carbamate to estradiol, with antineoplastic activity. Upon conversion
of alestramustine to estramustine, estramustine binds to microtubule-associated proteins
(MAPs) and beta tubulin, thereby interfering with microtubule dynamics and leading
to microtubule disassembly and cell cycle arrest. Due to the estrogen moiety, this
agent is able to selectively bind to and be taken up by estrogen receptor-positive
cells.;
UNII : 81U8A51CHK;
InChIKey : NRUFLTXGIPFVSH-KBVRNWHJSA-N;
CAS number : 139402-18-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 139402-18-9
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G-SRS /a ;
Chemical formula : C26H36Cl2N2O4;
Origin ID : C77370;
UMLS CUI : C2697985;
Semantic type(s)
- concept_is_in_subset
