Preferred Label : Calcifediol Anhydrous;
NCIt synonyms : 25-Hydroxycholescalciferol; 5,6-cis-25-Hydroxyvitamin D3; 25-Hydroxyvitamin D3; (5Z,7E)-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol; (3S,5Z,7E)-9,10-Secocholesta-5,7,10-Triene-3,25-Diol; Calcidiol; Cholecalciferol, 25-Hydroxy-; 25(OH)D3; (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol; 5,6-trans-25-Hydroxycholescalciferol; 25-Hydroxyvitamin D; (5Z,7E)-(3S)-9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol; 25-Hydroxycholecalciferol; 9,10-Secocholesta-5,7,10(19)-Triene-3beta,25-Diol; 5,6-trans-9,10-Seco-5,7,10(19)-Cholestatrien-3beta,25-Diol; 9,10-Secocholesta-5,7,10(19)-Triene-3,25-Diol, (3beta,5Z,7E)-;
NCIt definition : The anhydrous form of calcifediol, an orally available synthetic form of the calcitriol
prohormone calcifediol (25-hydroxyvitamin D), which can be used for vitamin D supplementation,
and with potential immunomodulating activity. Upon oral administration, calcifediol
is taken up by the body and converted, in the kidneys, to the active form calcitriol
(1,25-dihydroxyvitamin D or 1,25(OH)2D). This form increases and normalizes vitamin
D plasma levels, which, in turn, regulates calcium plasma levels, and normalizes elevated
parathyroid hormone (PTH) levels by suppressing both PTH synthesis, and secretion.
Vitamin D modulates and enhances the innate and adaptive immune responses. This may
improve unregulated inflammation and prevents the production of pro-inflammatory cytokines.
Specifically, vitamin D binds to its receptor vitamin D receptor (VDR) which is widely
expressed on immune cells and epithelial cells. This stimulates neutrophils, macrophages,
and natural killer (NK) cells, and activates epithelial cells to produce antimicrobial
peptides (AMPs). In addition, upon infection, vitamin D promotes the migration of
myeloid dendritic cells (mDCs) to lymphoid organs where they activate B- and T-lymphocytes.;
UNII : T0WXW8F54E;
InChIKey : JWUBBDSIWDLEOM-DTOXIADCSA-N;
CAS number : 19356-17-3;
Chemical formula : C27H44O2;
ChEBI ID : CHEBI:17933;
Origin ID : C77155;
UMLS CUI : C2713074;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
