Tasidotin - CISMeF

Preferred Label : Tasidotin;

NCIt definition : A third generation, synthetic, water-soluble, pentapeptide analog of the marine depsipeptide dolastatin 15, with potential antimitotic and antineoplastic activities. Tasidotin and its metabolite, tasidotin C-carboxylate, suppress the dynamic instability behavior of the microtubules through a reduction of the shortening rate (disassembly); reduction of the switching frequency from growth to shortening; and by reducing microtubules growth time. This may eventually result in a reduction of cell growth.;

UNII : 05G07285DK;

InChIKey : QMCOCIWNMHBIIA-LROMGURASA-N;

CAS number : 192658-64-3;

Molecule name : ILX651;

Chemical formula : C32H58N6O5;

Details

Origin ID

C77067;

UMLS CUI

C1610484;

Currated CISMeF NLP mapping
- tasidotin [MeSH concept]
- tasidotin [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tasidotin [MeSH Supplementary Concept]
- tasidotin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Tasidotin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Tasidotin Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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