Preferred Label : Rosabulin;
NCIt synonyms : 3-[(4-Cyanophenyl)methyl]-N-(3-methyl-5-isothiazolyl)-alpha-oxo-1-indolizineacetamide;
NCIt definition : A small molecule vascular disrupting agent, with potential antimitotic and antineoplastic
activities. Rosabulin binds to tubulin in a similar manner as colchicine and inhibits
microtubule assembly. This results in the disruption of the cytoskeleton of tumor
endothelial cells, ultimately leading to cell cycle arrest and blockage of cell division.
By destroying proliferating vascular cells, blood flow to the tumor is reduced and
eventually leads to a decrease in tumor cell proliferation.;
UNII : 6Z674O12T6;
InChIKey : IZZYUABKZYIINT-UHFFFAOYSA-N;
CAS number : 501948-05-6;
Molecule name : STA-5312;
Chemical formula : C22H16N4O2S;
Origin ID : C77066;
UMLS CUI : C2699098;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
