Cevipabulin - CISMeF

Preferred Label : Cevipabulin;

NCIt synonyms : Cevipabulinum; Tubulin Binding Agent TTI-237; TTI 237;

NCIt related terms : TTI-237;

NCIt definition : A synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin appears to bind at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.;

UNII : P14M0DWS2J;

InChIKey : ZUZPCOQWSYNWLU-VIFPVBQESA-N;

CAS number : 849550-05-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 849550-05-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C18H18ClF5N6O;

Codes from synonyms : CDR0000438726;

Details

Origin ID

C77064;

UMLS CUI

C2699167;

Currated CISMeF NLP mapping
- cevipabulin [MeSH concept]
- cevipabulin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cevipabulin [MeSH Supplementary Concept]
- cevipabulin [MeSH concept]
chemical_or_drug_affects_gene_product
- Tubulin [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Cevipabulin Fumarate [NCIt concept]
- Cevipabulin Succinate [NCIt concept]
has_target
- Tubulin [NCIt concept]
is_free_acid_or_base_form_of
- Cevipabulin Fumarate [NCIt concept]
- Cevipabulin Succinate [NCIt concept]

Keyword's position in hierarchy(ies) :

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