" /> Oteracil - CISMeF





Preferred Label : Oteracil;

NCIt synonyms : Oxonic Acid;

NCIt definition : A modulator of 5-fluorouracil (5-FU) activity and inhibitor of the enzyme orotate phosphoribosyl-transferase (OPRT), with chemoprotective activity. Oteracil preferentially localizes in the gastrointestinal (GI) tract where it inhibits OPRT, thereby decreasing metabolism of 5-FU into its active metabolite 5-fluorouridine-5'-monophosphate (FUMP). This decreases activated 5-FU-related gastrointestinal toxicity.;

UNII : 5VT6420TIG;

InChIKey : RYYCJUAHISIHTL-UHFFFAOYSA-N;

CAS number : 937-13-3;

Chemical formula : C4H3N3O4;

ChEBI ID : CHEBI:30863;

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29/05/2025


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