Preferred Label : Iron Dextran;
NCIt synonyms : Iron Dextran Complex; Iron Dextran Injection;
NCIt definition : A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran,
used as a form of parenteral iron-replacement therapy. Upon administration and absorption,
the iron dextran complex is removed from plasma by the reticuloendothelial system
which cleaves it into the components iron and dextran; ferric iron subsequently binds
to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is
transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated
into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb).
Use of this agent circumvents the gastrointestinal adverse effects commonly encountered
with the use of orally administered iron salt preparations. Because of cross-reactivity
with antibodies targeted against polysaccharides similar to dextran, anaphylactic
reactions may occur with this type of iron formulation.;
UNII : 95HR524N2M;
CAS number : 9004-66-4;
Drug name : Dexferrum; Ferrodex; Imferon; INFeD;
Chemical formula : HO(C6H10O5)n.Fe.3HO;
NCI Metathesaurus CUI : CL387295;
NSC code : 57682;
Codes from synonyms : 282;
Origin ID : C76837;
UMLS CUI : C0022092;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
