Golotimod - CISMeF

Preferred Label : Golotimod;

NCIt synonyms : Gamma-D-Glutamyl-L-Tryptophan; (2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic Acid; gamma-D-Glu-L-trp;

NCIt definition : An orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes, in particular the helper T (Th1) cells, activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression.;

UNII : 637C487Y09;

InChIKey : CATMPQFFVNKDEY-YPMHNXCESA-N;

CAS number : 229305-39-9;

Molecule name : SCV-07; SCV 07;

Chemical formula : C16H19N3O5;

Details

Origin ID

C76497;

UMLS CUI

C1173247;

Automatic exact mappings (from CISMeF team)
- golotimod [MeSH concept]
- golotimod [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- golotimod [MeSH Supplementary Concept]
- golotimod [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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