" /> Golotimod - CISMeF





Preferred Label : Golotimod;

NCIt synonyms : Gamma-D-Glutamyl-L-Tryptophan; (2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic Acid; gamma-D-Glu-L-trp;

NCIt definition : An orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes, in particular the helper T (Th1) cells, activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression.;

UNII : 637C487Y09;

InChIKey : CATMPQFFVNKDEY-YPMHNXCESA-N;

CAS number : 229305-39-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 229305-39-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SCV-07; SCV 07;

Chemical formula : C16H19N3O5;

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12/05/2024


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