Entecavir Anhydrous

Preferred Label : Entecavir Anhydrous;

NCIt definition : An anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.;

UNII : NNU2O4609D;

InChIKey : QDGZDCVAUDNJFG-FXQIFTODSA-N;

CAS number : 142217-69-4;

Chemical formula : C12H15N5O3;

ChEBI ID : CHEBI:473990;

Details

Origin ID

C76494;

UMLS CUI

C2699999;

Currated CISMeF NLP mapping
- Entecavir anhydrous (substance) [SNOMED CT concept]
- anhydrous entecavir [MeSH concept]
Manual NTBT mappings (CISMeF)
- Entecavir [ICD-11 Extension code]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Entecavir anhydrous (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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