Alkylating Agent-Related Myelodysplastic Syndrome

Preferred Label : Alkylating Agent-Related Myelodysplastic Syndrome;

NCIt synonyms : Alkylating Agent Related Myelodysplastic Syndrome;

NCIt related terms : Therapy-related myelodysplastic syndrome, alkylating agent related;

NCIt definition : A disorder seen following cancer chemotherapy. It is the most common cause of therapy-related myelodysplastic syndromes. It typically manifests several years after initiation of single or multi-agent chemotherapy with alkylators. Mutagenic potential of alkylating agents is believed to be age and cumulative dose-dependent. Deletions in chromosomes 5 and 7 are associated with susceptibility to this disorder. Clinical signs may include fatigue, dyspnea, bruising and frequent infections. Clinical course may progress to bone marrow failure or acute myeloid leukemia that is refractory to treatment. Prognosis is dismal with survivability usually less than one year.;

Neoplastic status : Malignant;

Details

Origin ID

C7643;

UMLS CUI

C1332235;

Automatic exact mappings (from CISMeF team)
- Therapy-related myelodysplastic syndrome (morphologic abnormality) [Inactive SNOMED CT concept]
- Therapy-related myelodysplastic syndrome, NOS [ICD-11 Extension code]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Bone Marrow Basophilia [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Pancytopenia [NCIt concept]
- Ring Sideroblasts 15 Percent or More of Erythroid Precursors [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Hypolobated Neutrophil [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neutrophil with Cytoplasmic Hypogranularity [NCIt concept]
disease_has_finding
- Bone Marrow Dysplasia Present [NCIt concept]
- Chemotherapeutic Agent Toxicity [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Myeloblasts Under 20 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Myeloblasts Under 20 Percent of Peripheral Blood White Cells [NCIt concept]
- Secondary Lesion [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 5 [NCIt concept]
- Human Chromosome 7 [NCIt concept]
disease_may_have_abnormal_cell
- Dysplastic Megakaryocyte [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 5 [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]

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