Epipodophyllotoxin-Related Myelodysplastic Syndrome

Preferred Label : Epipodophyllotoxin-Related Myelodysplastic Syndrome;

NCIt synonyms : Epipodophyllotoxin Related Myelodysplastic Syndrome;

NCIt related terms : Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related;

NCIt definition : A disorder seen following cancer chemotherapy. It typically manifests a few years after initiation of epipodophyllotoxin chemotherapy. Mutagenic potential of these non-intercalating DNA topoisomerase II inhibitors is believed to be increased with concurrent use of asparaginase or granulocyte colony-stimulating factor. Balanced translocations involving chromosomal bands 11q23 and 21q22 are commonly associated with this disorder. Clinical signs may include fatigue, dyspnea, bruising and frequent infections. Clinical course usually progresses to acute myeloid leukemia though most epipodophyllotoxin-related leukemias do not have an antecedent myelodysplastic phase. Prognosis is dismal with survivability usually less than one year.;

Neoplastic status : Malignant;

Détails

Origin ID

C7642;

UMLS CUI

C1333418;

Automatic exact mappings (from CISMeF team)
- Therapy-related myelodysplastic syndrome, NOS [ICD-11 Extension code]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
False UMLS correspondences (reviewed by CISMeF team)
- Therapy-related myelodysplastic syndrome, NOS [ICD-O code]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Bone Marrow Dysplasia Present [NCIt concept]
- Chemotherapeutic Agent Toxicity [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Myeloblasts Under 20 Percent of Bone Marrow Nucleated Cells [NCIt concept]
- Myeloblasts Under 20 Percent of Peripheral Blood White Cells [NCIt concept]
- Secondary Lesion [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Hypolobated Neutrophil [NCIt concept]
- Neutrophil with Cytoplasmic Hypogranularity [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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