NCIt synonyms : Epipodophyllotoxin Related Myelodysplastic Syndrome;
NCIt related terms : Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related;
NCIt definition : A disorder seen following cancer chemotherapy. It typically manifests a few years
after initiation of epipodophyllotoxin chemotherapy. Mutagenic potential of these
non-intercalating DNA topoisomerase II inhibitors is believed to be increased with
concurrent use of asparaginase or granulocyte colony-stimulating factor. Balanced
translocations involving chromosomal bands 11q23 and 21q22 are commonly associated
with this disorder. Clinical signs may include fatigue, dyspnea, bruising and frequent
infections. Clinical course usually progresses to acute myeloid leukemia though most
epipodophyllotoxin-related leukemias do not have an antecedent myelodysplastic phase.
Prognosis is dismal with survivability usually less than one year.;