NCIt definition : An inhibitor of the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R),
with antiplatelet activity. Upon administration, cangrelor selectively and reversibly
binds to P2Y12R, and blocks the platelet signaling pathway. This inhibits the activation
of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet
adhesion and aggregation.;