Preferred Label : Preladenant;
NCIt synonyms : 7H-Pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-;
NCIt definition : An orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with
potential immunomodulating and antineoplastic activities. Upon administration, preladenant
selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released
adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition
of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes,
and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled
receptor, is highly expressed on the cell surfaces of T-cells and, upon activation
by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced
by cancer cells and plays a key role in immunosuppression.;
UNII : 950O97NUPO;
InChIKey : DTYWJKSSUANMHD-UHFFFAOYSA-N;
CAS number : 377727-87-2;
Molecule name : MK-3814; SCH-420814;
Chemical formula : C25H29N9O3;
Origin ID : C76394;
UMLS CUI : C2698875;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
