Porfiromycin - CISMeF

Preferred Label : Porfiromycin;

NCIt synonyms : Methyl Mitomycin; Porphyromycin; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,[1aR-(1a-alpha,8beta, 8a-alpha,8b-alpha)]- (9CI); [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Methylmitomycin; Azirino[2',3':3,4]pyrrolo[1, 2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a, 8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester)(8CI);

NCIt related terms : Azirino[2',3':3,4]pyrrolo[1, 2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a, 8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester) (8CI); Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-1,5-dimethyl-,[1aR-(1a.alpha.,8.beta., 8a.alpha.,8b.alpha.)]- (9CI); MITOMYCIN, METHYL; ENT-50825; Mitomycin, methyl-; Methyl mitomycin C; Porfiromycine; N-Methylmitomycin C;

NCIt definition : An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.;

UNII : H1WK901OA6;

InChIKey : HRHKSTOGXBBQCB-VFWICMBZSA-N;

CAS number : 801-52-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 801-52-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Promycin;

Molecule name : U-14743; U-14,743; ENT-50825;

Chemical formula : C16H20N4O5;

NSC code : 56410;

Codes from synonyms : CDR0000045235; NSC0407676; NSC0056410;

Details

Origin ID

C763;

UMLS CUI

C0032697;

Automatic exact mappings (from CISMeF team)
- Porfiromycin [ICHI extension code]
Currated CISMeF NLP mapping
- Porfiromycin [ICD-11 Extension code]
- porfiromycin [MeSH Descriptor]
- porfiromycin [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Porfiromycin [ICD-11 Extension code]
- porfiromycin [MeSH concept]
- porfiromycin [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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