Preferred Label : Z, Rat Strain;
NCIt synonyms : Zucker; Z Rat Strain;
NCIt related terms : ZUC-leprfa;
NCIt definition : Derived from a spontaneous mutation in the leptin receptor that appeared in a 13M
rat colony bred at the Zucker Laboratory of Comparative Pathology (Stow, MA), genotype
leprfa. The Zucker rat may come in four principal color variants, including brown,
brown and white, black, and black and white. The mutation causes severe obesity, diabetes,
abnormal heart function, hypertriglyceridemia, and hypercholesterolemia. The Zucker
rat is utilized in biomedical research to study insulin resistance, glucose intolerance,
metabolic syndromes, and obesity.;
Alternative definition : CDISC: Derived from a spontaneous mutation in the leptin receptor that appeared in
a 13M rat colony bred at the Zucker Laboratory of Comparative Pathology (Stow, MA),
genotype leprfa.;
Origin ID : C76194;
UMLS CUI : C2700303;
Semantic type(s)
- concept_is_in_subset
