Preferred Label : Cilazapril Anhydrous;
NCIt definition : The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor
cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized
in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE,
thereby blocking the conversion of angiotensin I to angiotensin II. This prevents
the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation.
Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal
cortex, which leads to an increase in sodium excretion and subsequently increases
water outflow.;
UNII : 8Q9454114Q;
InChIKey : HHHKFGXWKKUNCY-FHWLQOOXSA-N;
CAS number : 88768-40-5;
Chemical formula : C22H31N3O5;
Origin ID : C76134;
UMLS CUI : C0886706;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
