" /> Cilazapril Monohydrate - CISMeF





Preferred Label : Cilazapril Monohydrate;

NCIt synonyms : Ro 31-2848 Monohydrate; Cilazapril; (1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid 9-ethyl Ester Monohydrate;

NCIt definition : A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : 19KW7PI29F;

InChIKey : JQRZBPFGBRIWSN-YOTVLOEGSA-N;

CAS number : 92077-78-6;

Chemical formula : C22H31N3O5.H2O;

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08/05/2025


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