Preferred Label : Corticorelin Acetate;
NCIt synonyms : Human Corticotropin-Releasing Factor; hCRF;
NCIt definition : The acetate salt form of coticorelin, a synthetic peptide of neurohormone corticotropin-releasing
factor (CRF), with potential antitumor and antiangiogenesis activities. Upon administration,
corticorelin stimulates adrenocorticotropic hormone (ACTH) secretion from the anterior
pituitary gland. In turn, ACTH stimulates cortisol production from the adrenal cortex
and is regulated by a negative feedback mechanism. Corticorelin appears to inhibit
swelling around brain tumors through reduction in vascular leakage and maintenance
of endothelial cell integrity. This agent potentially suppresses vascularization and
tumor cell growth through reduction of vascular endothelial growth factor (VEGF) that
appears to be via activation of corticotrophin-releasing factor receptor 2 (CRFR2),
a G protein-coupled receptor.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of brain cancer. It is made
naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory.
Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling)
of the brain. It is a type of neurohormone.;
UNII : 2YF82QN5RY;
CAS number : 86784-80-7;
Drug name : Xerecept;
Chemical formula : C208H344N60O63S2.C2H4O2;
Codes from synonyms : CDR0000415545;
PubMed : 19437022;
Origin ID : C76112;
UMLS CUI : C2699456;
Semantic type(s)
- concept_is_in_subset
