Tacrolimus Anhydrous

Preferred Label : Tacrolimus Anhydrous;

NCIt synonyms : Advagraf; Avagraf; Tsukubaenolide; Anhydrous Tacrolimus;

NCIt definition : Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.;

UNII : Y5L2157C4J;

InChIKey : QJJXYPPXXYFBGM-LFZNUXCKSA-N;

CAS number : 104987-11-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 104987-11-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : (-)-FK 506;

Chemical formula : C44H69NO12;

ChEBI ID : CHEBI:61049;

Details

Origin ID

C76066;

UMLS CUI

C0771204;

Currated CISMeF NLP mapping
- anhydrous tacrolimus [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tacrolimus anhydrous (substance) [SNOMED CT concept]
- anhydrous tacrolimus [MeSH concept]
Validated automatic mappings to NTBT
- tacrolimus [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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