" /> Tacrolimus Anhydrous - CISMeF





Preferred Label : Tacrolimus Anhydrous;

NCIt synonyms : Advagraf; Avagraf; Tsukubaenolide; Anhydrous Tacrolimus;

NCIt definition : Anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.;

UNII : Y5L2157C4J;

InChIKey : QJJXYPPXXYFBGM-LFZNUXCKSA-N;

CAS number : 104987-11-3;

Molecule name : (-)-FK 506;

Chemical formula : C44H69NO12;

ChEBI ID : CHEBI:61049;

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07/07/2025


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