Acute Myeloid Leukemia, Myelodysplasia-Related

Preferred Label : Acute Myeloid Leukemia, Myelodysplasia-Related;

NCIt synonyms : Acute Myeloid Leukemia with Multilineage Dysplasia; AML-MRC; Acute Myeloid Leukemia with Myelodysplasia-Related Changes;

NCIt related terms : AML with myelodysplasia-related changes;

NCIt definition : An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood, and either a previous history of myelodysplastic syndrome, multilineage dysplasia or myelodysplastic syndrome-related cytogenetic abnormalities. There is no history of prior cytotoxic therapy for an unrelated disorder, and there is absence of the molecular abnormalities that are present in acute myeloid leukemia with recurrent genetic abnormalities.;

Alternative definition : NICHD: An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood and one of the following: a previous history of myelodysplastic syndrome; multilineage dysplasia; or myelodysplastic syndrome-related cytogenetic abnormalities.;

Neoplastic status : Malignant;

ICD-O code : 9895/3;

Details

Origin ID

C7600;

UMLS CUI

C2825139;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukaemia with myelodysplasia-related changes [ICD-11 Subcategory]
Currated CISMeF NLP mapping
- Acute myeloid leukaemia with myelodysplasia-related changes [ICD-11 Extension code]
- Acute myeloid leukaemia with myelodysplasia-related features [ORDO Disease]
- Acute myeloid leukemia myelodysplasia related (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with multilineage dysplasia [ICD-O code]
- Acute myeloid leukemia with myelodysplasia-related changes (disorder) [SNOMED CT concept]
- acute myeloid leukemia and myelodysplasia [Disease (Nov.)]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Granulocytopenia [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Pancytopenia [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia myelodysplasia related (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with myelodysplasia-related changes (disorder) [SNOMED CT concept]
- acute myeloid leukemia and myelodysplasia [Disease (Nov.)]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Not Otherwise Specified Lesion [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
- Solid Growth Pattern [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_excludes_molecular_abnormality
- BCR-ABL1 Fusion Protein Expression [NCIt concept]
- TP53 Gene Mutation [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 20 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Bone Marrow Dysplasia Present in 50 Percent or More of the Cells of Two Cell Lines [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 11 [NCIt concept]
- Gain of Chromosome 19 [NCIt concept]
- Gain of Chromosome 21 [NCIt concept]
- Gain of Chromosome 8 [NCIt concept]
- Gain of Chromosome 9 [NCIt concept]
- Loss of Chromosome 11q ATM Gene Locus [NCIt concept]
- Loss of Chromosome 12p [NCIt concept]
- Loss of Chromosome 5q [NCIt concept]
- del(20)(q11) [NCIt concept]
- del(7)(q11;q36) [NCIt concept]
- t(3;5)(q25;q34) [NCIt concept]

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