Taltobulin - CISMeF

Preferred Label : Taltobulin;

NCIt definition : An analogue of the naturally occurring tripeptide hemiasterlin, with potential antimitotic and antineoplastic activities. Taltobulin binds tubulin in a similar manner as colchicine and inhibits tubulin polymerization. This results in the disruption of the cytoskeleton, ultimately leading to cell cycle arrest in G2/M phase, blockage of cell division and apoptosis.;

UNII : J6D6912BXS;

InChIKey : CNTMOLDWXSVYKD-PSRNMDMQSA-N;

CAS number : 228266-40-8;

Molecule name : HTI-286; SPA-110;

Chemical formula : C27H43N3O4;

Détails

Origin ID

C75998;

UMLS CUI

C1872680;

Automatic exact mappings (from CISMeF team)
- HTI-286 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- taltobulin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- taltobulin [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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