NCIt definition : A natural polyketide isolated from the myxobacteria Sorangium cellulosum with antifungal
activity. Ambruticin interferes with the osmoregulatory system by activating fungal
high osmolarity glycerol (HOG) pathway. This results in an accumulation of intracellular
glycerol, which in turn causes water influx and swelling of the cell. This ultimately
leads to cellular leakage and cell death.;